Did you know? The brain treats rejection like physical pain.
We all know that rejection hurts, but neuroscience has concluded that it does in fact, literally, hurt. While the brain does not process emotional pain and physical pain identically, the reaction and cascading events are very similar, and a natural chemical (painkiller mu-opioid) is released during both events. For example, when someone feels physical pain, opioids are released in the brain so that the significance of the pain is inhibited. We now know this same experience occurs when an individual feels slighted or rejected by others.
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Stu Dunn Blog 